Abnormal Calcium, Calcinosis, and Creatinine in Down's syndrome

The hypercalcaemia in association with trisomy 21 (Down's syndrome) is often not recognised and therefore underdiagnosed. Patients present the tetrad of hypercalcaemia, Down’s syndrome, renal impairment, nephrocalcinosis. 1-3 
 A 30-month old child syndrome had a long history nonspecific symptoms, constipation feeding difficulties. He was on excessive bottle feeds, taking 14 bottles daily, each six ounces milk. presented cardiac arrest having been unwell an acute illness. Blood tests showed hypercalcemia, raised urea creatinine which were explained by any other aetiologies. Post-mortem analysis pyelonephritis nephrocalcinosis.
 In children early detection introduction low calcium feeds may prevent morbidity mortality. Awareness monitoring serum levels along routine thyroid function Down would be important to such occurrences.